Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | MAOB | P27338 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | MAOA | P21397 | 2/20 | 0.62 |
| ▸ | CES2 | O00748 | 1/20 | 0.62 |
| ▸ | CES1 | P23141 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | ALPL | P05186 | 1/20 | 0.62 |
| ▸ | ALPI | P09923 | 1/20 | 0.62 |
| ▸ | ALPG | P10696 | 1/20 | 0.62 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.62 |
| ▸ | CRHBP | P24387 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6993037 | 1.00 | MAPT (0.62) | MAPTMAOBRAB9ANPC1MAOA | |
| SCHEMBL10523362 | 0.92 | MAPT (0.60) | MAPTMAOBRAB9ANPC1MAOA | |
| SCHEMBL11331924 | 0.92 | MAPT (0.60) | MAPTMAOBRAB9ANPC1MAOA | |
| SCHEMBL11606021 | 0.89 | MAPT (0.57) | MAPTMAOBRAB9ANPC1MAOA | |
| SCHEMBL10352737 | 0.87 | MAPT (0.56) | MAPTMAOBRAB9ANPC1MAOA | |
| SCHEMBL10352735 | 0.87 | MAPT (0.56) | MAPTMAOBRAB9ANPC1MAOA | |
| SCHEMBL8752642 | 0.86 | MAPT (0.63) | MAPTMAOBRAB9ANPC1MAOA | |
| SCHEMBL3038740 | 0.85 | MAOB (0.58) | MAPTMAOBRAB9ANPC1MAOA | |
| SCHEMBL3038749 | 0.85 | MAOB (0.58) | MAPTMAOBRAB9ANPC1MAOA | |
| SCHEMBL10705355 | 0.84 | MAPT (0.61) | MAPTMAOBRAB9ANPC1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921119-B1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-07-02 | — | — | EP | disclosed |
| US-6114360-A | Pyrrole compounds | ADIR ET COMPAGNIE (FR) | 2000-09-05 | — | — | US | disclosed |
| US-6063804-A | Pyrrole compounds | ADIR ET COMPAGNIE (FR) | 2000-05-16 | — | — | US | disclosed |
| EP-0921119-A1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-06-09 | — | — | EP | disclosed |