Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.58 |
| ▸ | CA9 | Q16790 | 3/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ACLY | P53396 | 2/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997478 | 0.82 | CA12 (0.60) | CA12CA9CA2CREBBPRECQL | |
| SCHEMBL3558164 | 0.80 | CA12 (0.78) | CA12CA9CA2CREBBPRECQL | |
| SCHEMBL3049725 | 0.80 | CA12 (0.52) | CA12CA9CA2CREBBPRECQL | |
| SCHEMBL7001508 | 0.77 | CA12 (0.51) | CA12CA9CA2CREBBPRECQL | |
| SCHEMBL1177272 | 0.74 | CA12 (0.58) | CA12CA9CA2CREBBPRECQL | |
| SCHEMBL3563271 | 0.73 | CA12 (0.56) | CA12CA9CA2RECQLALDH1A1 | |
| SCHEMBL28228343 | 0.73 | CA12 (0.56) | CA12CA9CA2RECQLALDH1A1 | |
| SCHEMBL4124528 | 0.73 | CA12 (0.53) | CA12CA9CA2CREBBPRECQL | |
| SCHEMBL30035312 | 0.73 | CA12 (0.53) | CA12CA9CA2CREBBPRECQL | |
| SCHEMBL5716839 | 0.72 | CA12 (0.55) | CA12CA9CA2CREBBPRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109785-B1 | INDOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF MALIGNANT AND OTHER DISEASES CAUSED BY PATHOLOGICAL CELL PROLIFERATION | ZENTARIS AG (DE) | 2003-01-02 | — | — | EP | disclosed |