Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 10/20 | 0.40 |
| ▸ | IGF1R | P08069 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.32 |
| ▸ | ULK1 | O75385 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2873675 | 0.85 | PAK1 (0.48) | PAK1JAK3CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL589156 | 0.85 | PAK1 (0.42) | PAK1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL31672493 | 0.85 | PAK1 (0.48) | PAK1JAK3CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL30454614 | 0.84 | CDK2 (0.44) | PAK1IGF1RJAK3CYP3A4CYP2D6 | |
| SCHEMBL589261 | 0.84 | CDK2 (0.44) | PAK1IGF1RJAK3CYP3A4CYP2D6 | |
| SCHEMBL589155 | 0.82 | PAK1 (0.41) | PAK1EGFRBTKJAK3PARP1 | |
| SCHEMBL589319 | 0.80 | CYP3A4 (0.43) | PAK1EGFRBTKCYP3A4CYP2D6 | |
| SCHEMBL30454154 | 0.80 | CYP3A4 (0.43) | PAK1EGFRBTKCYP3A4CYP2D6 | |
| SCHEMBL589781 | 0.80 | PAK1 (0.43) | PAK1JAK3CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL31672441 | 0.80 | KDR (0.46) | PAK1CYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343782-A1 | PYRIMIDINEAMINES AS ANGIOGENESIS MODULATORS | GLAXO GROUP LIMITED (GB) | 2003-09-17 | — | — | EP | claimed |
| WO-2002059110-A1 | PYRIMIDINEAMINES AS ANGIOGENESIS MODULATORS | GLAXO GROUP LIMITED (GB) | 2002-08-01 | — | — | WO | claimed |