Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.35 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | HTR3A | P46098 | 2/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990659 | 0.90 | PTAFR (0.42) | HRH1MAPK1MEN1MAPTKMT2A | |
| Fumaric Acid SCHEMBL6996855 | 0.86 | MAPK1 (0.48) | HRH1MAPK1MEN1MAPTKMT2A | |
| Fumaric Acid SCHEMBL6996858 | 0.86 | MAPK1 (0.48) | HRH1MAPK1MEN1MAPTKMT2A | |
| SCHEMBL6990175 | 0.86 | HRH1 (0.48) | HRH1MAPK1MEN1MAPTKMT2A | |
| Fumaric Acid SCHEMBL9282740 | 0.84 | MAPK1 (0.60) | HRH1MAPK1MEN1MAPTKMT2A | |
| SCHEMBL6988823 | 0.83 | HRH1 (0.52) | HRH1MAPK1MEN1MAPTKMT2A | |
| SCHEMBL6996608 | 0.79 | HRH1 (0.41) | HRH1MAPTCYP2D6CYP2C19LMNA | |
| SCHEMBL6993068 | 0.76 | MEN1 (0.31) | HRH1MAPK1MEN1MAPTKMT2A | |
| SCHEMBL6996281 | 0.76 | OPRK1 (0.36) | HRH1MAPK1MEN1MAPTKMT2A | |
| Water SCHEMBL7169111 | 0.72 | PTAFR (0.41) | HRH1PTAFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588859-B1 | Imidazo[1,2-a](pyrrolo, thieno or furano)[3,2-d]azepine derivatives, compositions and methods of use | JANSSEN PHARMACEUTICA NV (BE) | 2003-08-13 | — | — | EP | claimed |