Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.31 |
| ▸ | PHGDH | O43175 | 1/20 | 0.31 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.31 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7000492 | 1.00 | SERPINE1 (0.37) | SERPINE1HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL6993531 | 1.00 | SERPINE1 (0.37) | SERPINE1HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL7019336 | 0.91 | SERPINE1 (0.37) | SERPINE1SYKMAPTNPSR1TDP1 | |
| SCHEMBL6996062 | 0.87 | SERPINE1 (0.37) | SERPINE1HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL6986607 | 0.87 | SERPINE1 (0.37) | SERPINE1HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL6986606 | 0.87 | SERPINE1 (0.37) | SERPINE1HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL6989772 | 0.85 | HDAC3 (0.41) | SERPINE1HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL6989769 | 0.85 | HDAC3 (0.41) | SERPINE1HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL6992685 | 0.85 | HDAC3 (0.41) | SERPINE1HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL7001569 | 0.84 | SERPINE1 (0.37) | SERPINE1HDAC3HDAC4HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846111-B1 | SYNTHESES OF OPTICALLY PURE COMPOUNDS USEFUL AS GARFT INHIBITORS AND THEIR INTERMEDIATES | AGOURON PHARMA (US) | 2003-08-27 | — | — | EP | disclosed |
| US-5981748-A | Synthesis of optically pure compounds useful as GARFT inhibitors and their intermediates | AGOURON PHARMACEUTICALS, INC. (US) | 1999-11-09 | — | — | US | disclosed |
| US-5831100-A | Syntheses of optically pure compounds useful as GARFT inhibitors and their intermediates | AGOURON PHARMACEUTICALS, INC. (US) | 1998-11-03 | — | — | US | disclosed |
| EP-0846111-A1 | SYNTHESES OF OPTICALLY PURE COMPOUNDS USEFUL AS GARFT INHIBITORS AND THEIR INTERMEDIATES | AGOURON PHARMACEUTICALS, INC. (US) | 1998-06-10 | — | — | EP | disclosed |
| WO-1996040674-A1 | SYNTHESES OF OPTICALLY PURE COMPOUNDS USEFUL AS GARFT INHIBITORS AND THEIR INTERMEDIATES | AGOURON PHARMACEUTICALS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |