Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986607 | 1.00 | SERPINE1 (0.37) | SERPINE1HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL6996062 | 1.00 | SERPINE1 (0.37) | SERPINE1HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL6993531 | 0.87 | SERPINE1 (0.37) | SERPINE1HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL7000492 | 0.87 | SERPINE1 (0.37) | SERPINE1HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL6993528 | 0.87 | SERPINE1 (0.37) | SERPINE1HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL7092530 | 0.85 | SERPINE1 (0.37) | SERPINE1HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL7092531 | 0.85 | SERPINE1 (0.37) | SERPINE1HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL6989769 | 0.84 | HDAC3 (0.41) | SERPINE1HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL6989772 | 0.84 | HDAC3 (0.41) | SERPINE1HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL6992685 | 0.84 | HDAC3 (0.41) | SERPINE1HDAC3HDAC4HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846111-B1 | SYNTHESES OF OPTICALLY PURE COMPOUNDS USEFUL AS GARFT INHIBITORS AND THEIR INTERMEDIATES | AGOURON PHARMA (US) | 2003-08-27 | — | — | EP | disclosed |
| US-5981748-A | Synthesis of optically pure compounds useful as GARFT inhibitors and their intermediates | AGOURON PHARMACEUTICALS, INC. (US) | 1999-11-09 | — | — | US | disclosed |
| EP-0846111-A1 | SYNTHESES OF OPTICALLY PURE COMPOUNDS USEFUL AS GARFT INHIBITORS AND THEIR INTERMEDIATES | AGOURON PHARMACEUTICALS, INC. (US) | 1998-06-10 | — | — | EP | disclosed |
| WO-1996040674-A1 | SYNTHESES OF OPTICALLY PURE COMPOUNDS USEFUL AS GARFT INHIBITORS AND THEIR INTERMEDIATES | AGOURON PHARMACEUTICALS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |