Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.72 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | HTT | P42858 | 1/20 | 0.72 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.57 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | BCL6 | P41182 | 1/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6991387 | 0.92 | EGFR (0.77) | EGFRERBB2HPGDHTTGPR119 | |
| SCHEMBL8317606 | 0.88 | EGFR (0.72) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8488100 | 0.87 | EGFR (0.74) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL6994160 | 0.87 | EGFR (0.76) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL7144902 | 0.86 | EGFR (0.53) | EGFRERBB2HPGDHTTGPR119 | |
| SCHEMBL8317587 | 0.86 | EGFR (0.53) | EGFRERBB2HPGDHTTGPR119 | |
| SCHEMBL8317727 | 0.86 | EGFR (0.74) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL6998951 | 0.86 | EGFR (0.56) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8649189 | 0.85 | EGFR (0.64) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8486972 | 0.85 | EGFR (0.64) | EGFRERBB2HPGDHTTCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | disclosed |