Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.48 |
| ▸ | BRAF | P15056 | 4/20 | 0.47 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997349 | 0.89 | EGFR (0.57) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL7582468 | 0.87 | EGFR (0.51) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL7582476 | 0.87 | EGFR (0.51) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6993850 | 0.86 | EGFR (0.72) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6988538 | 0.86 | EGFR (0.54) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6986988 | 0.85 | EGFR (0.72) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8317587 | 0.85 | EGFR (0.53) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8316553 | 0.82 | EGFR (0.58) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8316549 | 0.82 | EGFR (0.58) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL7603145 | 0.82 | EGFR (0.52) | EGFRERBB2HPGDHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | disclosed |