Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | STK4 | Q13043 | 6/20 | 0.43 |
| ▸ | STK3 | Q13188 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998717 | 0.88 | EGFR (0.45) | EGFRERBB2SRCSTK4STK3 | |
| SCHEMBL2200535 | 0.87 | EGFR (0.57) | EGFRERBB2SRCSTK4STK3 | |
| SCHEMBL2203851 | 0.82 | EGFR (0.53) | EGFRERBB2SRCSTK4STK3 | |
| SCHEMBL2205116 | 0.76 | EGFR (0.74) | EGFRERBB2SRCSTK4STK3 | |
| SCHEMBL2205129 | 0.76 | EGFR (0.74) | EGFRERBB2SRCSTK4STK3 | |
| SCHEMBL6999406 | 0.75 | EGFR (0.56) | EGFRERBB2SRCSTK4STK3 | |
| SCHEMBL7000625 | 0.73 | MAP2K1 (0.53) | EGFRERBB2STK4STK3MAP2K1 | |
| SCHEMBL6999369 | 0.72 | EGFR (0.58) | EGFRERBB2SRCSTK4STK3 | |
| SCHEMBL6385932 | 0.72 | EGFR (0.69) | EGFRERBB2 | |
| SCHEMBL6383067 | 0.72 | EGFR (0.69) | EGFRERBB2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | claimed |