Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.45 |
| ▸ | STK4 | Q13043 | 9/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | STK3 | Q13188 | 3/20 | 0.40 |
| ▸ | STK25 | O00506 | 1/20 | 0.39 |
| ▸ | CIT | O14578 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | STK17B | O94768 | 1/20 | 0.39 |
| ▸ | STK10 | O94804 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | FES | P07332 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | YES1 | P07947 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994196 | 0.88 | EGFR (0.47) | EGFRERBB2STK4SRCSTK3 | |
| SCHEMBL2203851 | 0.88 | EGFR (0.53) | EGFRERBB2STK4SRCSTK3 | |
| SCHEMBL2200535 | 0.81 | EGFR (0.57) | EGFRERBB2STK4SRCSTK3 | |
| SCHEMBL6998421 | 0.77 | EGFR (0.56) | EGFRERBB2STK4SRCSTK3 | |
| SCHEMBL2205129 | 0.75 | EGFR (0.74) | EGFRERBB2STK4SRCSTK3 | |
| SCHEMBL2205116 | 0.75 | EGFR (0.74) | EGFRERBB2STK4SRCSTK3 | |
| SCHEMBL6995272 | 0.74 | MAP2K1 (0.50) | EGFRERBB2STK4STK3MAP2K1 | |
| SCHEMBL6382063 | 0.74 | EGFR (0.66) | EGFRERBB2SRC | |
| SCHEMBL6996969 | 0.74 | EGFR (0.57) | EGFRERBB2STK4SRCSTK3 | |
| SCHEMBL6383813 | 0.74 | EGFR (0.65) | EGFRERBB2GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | claimed |