SCHEMBL6994558

SCHEMBL6994558

C1=CC=C2SC=CN2C=C1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8103420 0.69
SCHEMBL2994409 0.57
SCHEMBL1127083 0.54
SCHEMBL2353971 0.53
SCHEMBL2353974 0.48
SCHEMBL27675090 0.46
SCHEMBL28133321 0.46
SCHEMBL21500439 0.45
SCHEMBL5944764 0.41
SCHEMBL23234265 0.40 MEN1 (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0719779-B1 SUBSTITUTED THIAZOLO [3,2-ALPHA]AZEPINE DERIVATIVE EISAI CO LTD (JP) 2003-11-19 EP claimed
EP-0719779-A1 SUBSTITUTED THIAZOLO [3,2-ALPHA]AZEPINE DERIVATIVE Eisai Co., Ltd. (JP) 1996-07-03 EP claimed
JP-8165293-A None JP disclosed
EP-0719779-B1 SUBSTITUTED THIAZOLO [3,2-ALPHA]AZEPINE DERIVATIVE EISAI CO LTD (JP) 2003-11-19 EP disclosed
WO-2003045909-A2 METHODS AND INTERMEDIATES FOR THE SYNTHESIS OF AZEPINES SMITHKLINE BEECHAM CORPORATION (US) 2003-06-05 WO disclosed
CN-1053908-C Substituted thiazolo [3, 2-alpha ] aza * derivatives EISAI CO LTD (JP) 2000-06-28 CN disclosed
CN-1053908-C Substituted thiazolo [3, 2-alpha ] aza * derivatives EISAI CO LTD (JP) 2000-06-28 CN disclosed
US-6051705-A HAVING INHIBITORY ACTIVITY AGAINST ANGIOTENSIN I CONVERTING ENZYME AND NEUTRAL ENDPEPTIDASE EISAI CO., LTD. (JP) 2000-04-18 US disclosed
US-6051705-A HAVING INHIBITORY ACTIVITY AGAINST ANGIOTENSIN I CONVERTING ENZYME AND NEUTRAL ENDPEPTIDASE EISAI CO., LTD. (JP) 2000-04-18 US disclosed
US-6051705-A HAVING INHIBITORY ACTIVITY AGAINST ANGIOTENSIN I CONVERTING ENZYME AND NEUTRAL ENDPEPTIDASE EISAI CO., LTD. (JP) 2000-04-18 US disclosed
WO-1997017972-A1 CHOLESTEROL-LOWERING COMPOSITION EISAI CO., LTD. (JP) 1997-05-22 WO disclosed
CN-1134152-A Substituted thiazolo [3, 2-alpha ] aza * derivatives EISAI CO LTD (JP) 1996-10-23 CN disclosed
CN-1134152-A Substituted thiazolo [3, 2-alpha ] aza * derivatives EISAI CO LTD (JP) 1996-10-23 CN disclosed
EP-0719779-A1 SUBSTITUTED THIAZOLO [3,2-ALPHA]AZEPINE DERIVATIVE Eisai Co., Ltd. (JP) 1996-07-03 EP disclosed
EP-0719779-A1 SUBSTITUTED THIAZOLO [3,2-ALPHA]AZEPINE DERIVATIVE Eisai Co., Ltd. (JP) 1996-07-03 EP disclosed
JP-H08165293-A SUBSTITUTED THIAZOLO(3,2-A)AZEPINE DERIVATIVE EISAI CO LTD 1996-06-25 JP disclosed