Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | WNT3A | P56704 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6754934 | 0.88 | CTNNB1 (0.49) | CASP1CYP1A2CYP2C9POLBTHRB | |
| SCHEMBL6626291 | 0.85 | MEN1 (0.49) | CASP1CYP1A2CYP2C9POLBTHRB | |
| SCHEMBL6749524 | 0.81 | CYP1A2 (0.46) | CASP1CYP1A2CYP2C9POLBTHRB | |
| SCHEMBL6753020 | 0.79 | MAPT (0.53) | CTNNB1WNT3AALDH1A1NPSR1SRD5A2 | |
| SCHEMBL10999598 | 0.79 | KDM4E (0.54) | CASP1CYP1A2CYP2C9POLBTHRB | |
| SCHEMBL3523469 | 0.77 | MAPT (0.61) | CASP1CYP1A2CYP2C9POLBTHRB | |
| SCHEMBL6752817 | 0.76 | CYP1A2 (0.43) | CASP1CYP1A2CYP2C9POLBTHRB | |
| SCHEMBL3519622 | 0.76 | CASP1 (0.85) | CASP1CYP1A2CYP2C9POLBTHRB | |
| SCHEMBL6753683 | 0.76 | MAPT (0.53) | ALDH1A1NPSR1KDM4ETSHRSRD5A2 | |
| SCHEMBL11856611 | 0.76 | MAPT (0.55) | CASP1CYP1A2CYP2C9POLBTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015457-B1 | 1,3-DIOXOLO/4,5-H//2,3/BENZODIAZEPINE DERIVATIVES AS AMPA/KAINATE RECEPTOR INHIBITORS | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 2003-11-26 | — | — | EP | disclosed |
| EP-1003749-B1 | 8-SUBSTITUTED-9H-1,3-DIOXOLO/4,5-h/2,3/BENZODIAZEPINE DERIVATES, AS AMPA/KAINATERECEPTOR INHIBITORS | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 2003-10-22 | — | — | EP | disclosed |
| US-6562810-B1 | Competitive AMPA/kainite antagonist properties making them useful in the treatment of diseases where inhibition of the AMPA/kainite receptors may a favorable effect | EGIS GYOGYSZERGYAR RT. (HU) | 2003-05-13 | — | — | US | disclosed |
| WO-2000053166-A2 | USE OF CONDENSED 2,3-BENZODIAZEPINE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF DISEASES RELATED TO THE INHIBITION OF LIPID PEROXIDATION | EGIS Gyógyszergyár Rt. (HU) | 2000-09-14 | — | — | WO | disclosed |