Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986828 | 0.79 | FTO (0.38) | FTOHPGDTSHRHSD17B10 | |
| SCHEMBL6992092 | 0.71 | MAPT (0.50) | HPGDTDP1 | |
| SCHEMBL11850892 | 0.68 | FTO (0.40) | FTOTDP1 | |
| SCHEMBL26768896 | 0.67 | FTO (0.40) | FTOHSD17B10 | |
| SCHEMBL26767281 | 0.66 | CNR2 (0.42) | FTOHPGD | |
| SCHEMBL3238540 | 0.61 | PPARG (0.44) | FTOHPGDTSHRHSD17B10TDP1 | |
| SCHEMBL9327955 | 0.61 | FTO (0.61) | FTOHPGDTSHRHSD17B10TDP1 | |
| SCHEMBL3246809 | 0.60 | PPARA (0.46) | FTO | |
| SCHEMBL10357236 | 0.60 | HSD17B10 (0.67) | HPGDTSHRHSD17B10TDP1 | |
| SCHEMBL30633867 | 0.60 | AHR (0.68) | FTOHPGDTSHRHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863906-B1 | HETEROCYCLIC DIOXETHANE SUBSTRATES, PROCESS FOR THEIR PREPARATION AND THEIR USE | ROCHE DIAGNOSTICS GMBH (DE) | 2003-02-12 | — | — | EP | disclosed |
| US-6107036-A | Heterocyclic dioxethane substrates, process for their preparation and their use | ROCHE DIAGNOSTICS GMBH (DE) | 2000-08-22 | — | — | US | disclosed |
| EP-0863906-A2 | HETEROCYCLIC DIOXETHANE SUBSTRATES, PROCESS FOR THEIR PREPARATION AND THEIR USE | Roche Diagnostics GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997014696-A2 | HETEROCYCLIC DIOXETHANE SUBSTRATES, PROCESS FOR THEIR PREPARATION AND THEIR USE | BOEHRINGER MANNHEIM GMBH (DE) | 1997-04-24 | — | — | WO | disclosed |