Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 2/20 | 0.53 |
| ▸ | PLK1 | P53350 | 11/20 | 0.47 |
| ▸ | KDR | P35968 | 9/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7232580 | 0.85 | KDR (0.63) | FYNPLK1KDRIGF1RIKBKB | |
| Hydrochloric Acid SCHEMBL7000614 | 0.84 | KDR (0.64) | FYNPLK1KDRCDK2CDK9 | |
| SCHEMBL7001153 | 0.83 | FYN (0.56) | FYNPLK1KDRIGF1RIKBKB | |
| Hydrochloric Acid SCHEMBL7090934 | 0.82 | FYN (0.62) | FYNPLK1KDRIGF1RAXL | |
| SCHEMBL7241122 | 0.81 | FYN (0.65) | FYNPLK1KDRIGF1RIKBKB | |
| Hydrochloric Acid SCHEMBL7242637 | 0.80 | FYN (0.59) | FYNPLK1KDRIGF1RIKBKB | |
| SCHEMBL7240552 | 0.80 | FYN (0.55) | FYNPLK1KDRIGF1RIKBKB | |
| SCHEMBL7231388 | 0.80 | FYN (0.61) | FYNPLK1KDRCDK2IGF1R | |
| Hydrochloric Acid SCHEMBL7232574 | 0.79 | PLK1 (0.64) | FYNPLK1KDRIGF1RIKBKB | |
| Hydrochloric Acid SCHEMBL7240228 | 0.79 | FYN (0.65) | FYNPLK1KDRIGF1RIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0989985-B1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-11-05 | — | — | EP | disclosed |
| US-6133257-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-10-17 | — | — | US | disclosed |
| EP-0989985-A1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-04-05 | — | — | EP | disclosed |
| WO-1998058926-A1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-12-30 | — | — | WO | disclosed |