Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 9/20 | 0.52 |
| ▸ | FNTB | P49356 | 9/20 | 0.52 |
| ▸ | HRH1 | P35367 | 10/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6993629 | 0.84 | HRH1 (0.69) | FNTAFNTBHRH1MEN1LMNA | |
| SCHEMBL6991026 | 0.81 | HRH1 (0.41) | FNTAFNTBHRH1MEN1LMNA | |
| SCHEMBL6996008 | 0.77 | FNTA (0.71) | FNTAFNTBHRH1CHRM2HTR1A | |
| SCHEMBL9734604 | 0.76 | FNTA (0.58) | FNTAFNTBHRH1MEN1LMNA | |
| SCHEMBL9207035 | 0.76 | FNTA (0.58) | FNTAFNTBHRH1MEN1LMNA | |
| SCHEMBL6993665 | 0.73 | FNTA (0.56) | FNTAFNTBHRH1MEN1LMNA | |
| SCHEMBL9374487 | 0.72 | PTAFR (0.73) | FNTAFNTBHRH1PTAFRSLC6A15 | |
| SCHEMBL9214088 | 0.71 | FNTA (0.75) | FNTAFNTBHRH1PTAFR | |
| SCHEMBL6996504 | 0.71 | FNTA (0.51) | FNTAFNTBHRH1MEN1LMNA | |
| SCHEMBL9563106 | 0.70 | FNTA (0.78) | FNTAFNTBHRH1PTAFRSLC6A15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021448-B1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY AS Ras-FPT INHIBITORS | SCHERING CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6130229-A | Tricyclic compounds having activity as RAS-FPT inhibitors | SCHERING CORPORATION (US) | 2000-10-10 | — | — | US | disclosed |