SCHEMBL6995053

SCHEMBL6995053

CC1=C(N)Nc2cc(CC(C)N(Cc3ccccc3)C(=O)OC(C)(C)C)ccc2O1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.34
HSD17B10 Q99714 2/20 0.34
LMNA P02545 2/20 0.34
ALDH1A1 P00352 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
HDAC3 O15379 1/20 0.34
HDAC1 Q13547 1/20 0.34
HDAC2 Q92769 1/20 0.34
NCOR2 Q9Y618 1/20 0.34
SLC7A5 Q01650 1/20 0.33
TSHR P16473 1/20 0.33
ALOX15 P16050 1/20 0.33
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
AKT1 P31749 2/20 0.32
ABCB1 P08183 1/20 0.32
TRPM8 Q7Z2W7 1/20 0.32
ATM Q13315 1/20 0.31
PTGES O14684 1/20 0.31
PARP1 P09874 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7704910 0.86 HDAC1 (0.45) HSD17B10ALDH1A1HDAC3HDAC1HDAC2
SCHEMBL7710216 0.84 HSD17B10 (0.35) POLBHSD17B10LMNAALDH1A1L3MBTL1
SCHEMBL7710846 0.81 PARP1 (0.53) HSD17B10ALDH1A1L3MBTL1ALOX15PARP1
SCHEMBL7093398 0.80 PARP1 (0.41) POLBHSD17B10LMNAALDH1A1L3MBTL1
SCHEMBL7711366 0.79 HDAC1 (0.37) ALDH1A1HDAC3HDAC1HDAC2NCOR2
SCHEMBL7708189 0.79 HDAC3 (0.37) POLBHSD17B10LMNAALDH1A1HDAC3
SCHEMBL6302692 0.78 BRD4 (0.38) POLBL3MBTL1HDAC3HDAC1HDAC2
SCHEMBL7704965 0.77 HDAC3 (0.36) POLBLMNAALDH1A1HDAC3HDAC1
SCHEMBL7708353 0.77 GRM2 (0.37) LMNAALDH1A1HDAC3HDAC1HDAC2
SCHEMBL7711248 0.77 RIPK1 (0.37) LMNAALDH1A1HDAC3HDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1015437-B1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AG (DE) 2003-12-03 EP disclosed
US-6365736-B1 TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. SCHERING AKTIENGESELLSCHAFT (DE) 2002-04-02 US disclosed