Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.75 |
| ▸ | PTPRC | P08575 | 1/20 | 0.60 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.50 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL206335 | 0.92 | CES1 (0.79) | CES1PTPRCPABPC1DNMT1PTGS2 | |
| SCHEMBL9673279 | 0.92 | CES1 (0.89) | CES1PTPRCPABPC1DNMT1PTGS2 | |
| SCHEMBL29915354 | 0.86 | CES1 (0.71) | CES1PTPRCPABPC1DNMT1PTGS2 | |
| SCHEMBL9674046 | 0.86 | CES1 (0.71) | CES1PTPRCPABPC1DNMT1PTGS2 | |
| SCHEMBL30448645 | 0.86 | CES1 (1.00) | CES1PTPRCPABPC1DNMT1PTGS2 | |
| SCHEMBL31141849 | 0.80 | PTPRC (0.91) | CES1PTPRCPABPC1DNMT1MEN1 | |
| SCHEMBL12288017 | 0.79 | CES1 (0.60) | CES1PTPRCPABPC1DNMT1PTGS2 | |
| SCHEMBL5746932 | 0.76 | CES1 (0.46) | CES1PTPRCPABPC1DNMT1 | |
| SCHEMBL14269097 | 0.76 | CES1 (0.46) | CES1PTPRCPABPC1DNMT1PTGS2 | |
| SCHEMBL18384494 | 0.76 | MAOA (0.58) | CES1PTPRCPABPC1DNMT1CDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200109228-A1 | CROSSLINKED POLYMERS AND RELATED COMPOSITIONS, ELECTROCHEMICAL CELLS, BATTERIES, METHODS AND SYSTEMS | LINOVA ENERGY INC. | 2020-04-09 | — | — | US | disclosed |
| US-7332615-B2 | Hydrophilic analogs of 4,8-dihydrobenzodithiophene-4,8-diones as anticancer agents | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2008-02-19 | — | — | US | disclosed |
| EP-1093456-B1 | NAPHTHO- AND DIHYDROBENZO-THIOPHENE DERIVATIVES AS CYTOTOXIC ANTITUMOR AGENTS | UNIV NORTH CAROLINA (US) | 2003-12-17 | — | — | EP | disclosed |
| US-6337346-B1 | BENZODITHIOPHENE DERIVATIVES | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2002-01-08 | — | — | US | disclosed |
| EP-1097152-A2 | SYNTHESIS OF COMPOUNDS USEFUL IN THE MANUFACTURE OF KETOROLAC | Mallinckrodt Inc. (US) | 2001-05-09 | — | — | EP | disclosed |
| EP-1093456-A2 | NAPHTHO- AND DIHYDROBENZO-THIOPHENE DERIVATIVES AS CYTOTOXIC ANTITUMOR AGENTS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2001-04-25 | — | — | EP | disclosed |
| US-6174913-B1 | TREATING TUMOR BY ADMINISTERING COMPOUNDS E.G.:2-ACETYL-NAPHTHO(2,3-B)THIOPHENE-4,9-DIONE; 2,7-DIACETYL-NAPHTHO(2,3-B)THIOPHENE-4,9-DIONE | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2001-01-16 | — | — | US | disclosed |
| WO-1999062909-A9 | NAPHTHO- AND DIHYDROBENZO-THIOPHENE DERIVATIVES AS CYTOTOXIC ANTITUMOR AGENTS | UNIV NORTH CAROLINA (US) | 2000-04-27 | — | — | WO | disclosed |
| WO-2000002855-A2 | SYNTHESIS OF COMPOUNDS USEFUL IN THE MANUFACTURE OF KETOROLAC | MALLINCKRODT INC. (US) | 2000-01-20 | — | — | WO | disclosed |
| WO-1999062909-A2 | NAPHTHO- AND DIHYDROBENZO-THIOPHENE DERIVATIVES AS CYTOTOXIC ANTITUMOR AGENTS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-12-09 | — | — | WO | disclosed |