Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994733 | 1.00 | HTR1A (0.43) | HTR1AADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL14460702 | 0.84 | HTR1A (0.45) | HTR1AADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL14476208 | 0.84 | HTR1A (0.45) | HTR1AADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL23644285 | 0.82 | MCHR1 (0.45) | HTR1AADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL7099002 | 0.81 | HTR1A (0.43) | HTR1AADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL23645076 | 0.81 | HTR1A (0.43) | HTR1AADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL7097954 | 0.81 | HTR1A (0.43) | HTR1AADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL23644281 | 0.81 | HTR1A (0.43) | HTR1AADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL12635156 | 0.81 | HTR1A (0.43) | HTR1AADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL12635140 | 0.81 | HTR1A (0.43) | HTR1AADRA2AADRA2BADRA2CHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370558-A1 | PIPERAZINE- AND PIPERIDINE-DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002059117-A1 | PIPERAZINE- AND PIPERIDINE-DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2002-08-01 | — | — | WO | disclosed |