Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.61 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.61 |
| ▸ | PDE1A | P54750 | 3/20 | 0.61 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.61 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.61 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.61 |
| ▸ | PDE2A | O00408 | 1/20 | 0.61 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.61 |
| ▸ | PDE6D | O43924 | 1/20 | 0.61 |
| ▸ | PDE8A | O60658 | 1/20 | 0.61 |
| ▸ | PDE9A | O76083 | 1/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.61 |
| ▸ | PDE6A | P16499 | 1/20 | 0.61 |
| ▸ | PDE6G | P18545 | 1/20 | 0.61 |
| ▸ | PDE4A | P27815 | 1/20 | 0.61 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7004007 | 0.94 | PDE5A (0.62) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL5595162 | 0.87 | PDE5A (0.78) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL7002163 | 0.86 | PDE5A (0.64) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL6333017 | 0.85 | PDE5A (0.72) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL6332588 | 0.82 | PDE5A (0.70) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL6774601 | 0.82 | PDE5A (0.70) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL5595239 | 0.82 | PDE5A (0.68) | PDE5APDE3BPDE3APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL7002986 | 0.82 | PDE5A (0.67) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL6340020 | 0.82 | PDE5A (0.76) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL6334468 | 0.82 | PDE5A (0.76) | PDE5APDE3BPDE3APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123296-B1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LTD (GB) | 2003-09-17 | — | — | EP | disclosed |