Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 17/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | NMT1 | P30419 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7003907 | 0.97 | CRHR1 (0.39) | CRHR1MEN1NR1I2GMNNLMNA | |
| SCHEMBL6996246 | 0.95 | CRHR1 (0.35) | CRHR1MEN1NR1I2GMNNLMNA | |
| SCHEMBL6996135 | 0.92 | CRHR1 (0.35) | CRHR1MEN1NR1I2GMNNLMNA | |
| SCHEMBL6997366 | 0.89 | CRHR1 (0.35) | CRHR1NMT1 | |
| SCHEMBL6999813 | 0.88 | CRHR1 (0.30) | CRHR1 | |
| SCHEMBL7000023 | 0.87 | CRHR1 (0.38) | CRHR1 | |
| SCHEMBL7002229 | 0.86 | CRHR1 (0.35) | CRHR1NMT1 | |
| SCHEMBL6997210 | 0.86 | CRHR1 (0.36) | CRHR1 | |
| SCHEMBL7001309 | 0.85 | CRHR1 (0.31) | CRHR1 | |
| SCHEMBL7000593 | 0.84 | CRHR1 (0.38) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090005-B1 | PYRAZOLO 1,5-a]TRIAZINE CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2003-08-20 | — | — | EP | claimed |
| US-6509338-B1 | Psychiatric disorders and neurological diseases including affective disorder, anxiety, depression, headache, irritable bowel syndrome, post-traumatic stress disorder, supranuclear palsy, immune suppression, Alzheimer's disease, | BRISTOL-MYERS SQUIBB COMPANY | 2003-01-21 | — | — | US | claimed |
| EP-1090005-B1 | PYRAZOLO 1,5-a]TRIAZINE CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2003-08-20 | — | — | EP | disclosed |
| US-6509338-B1 | Psychiatric disorders and neurological diseases including affective disorder, anxiety, depression, headache, irritable bowel syndrome, post-traumatic stress disorder, supranuclear palsy, immune suppression, Alzheimer's disease, | BRISTOL-MYERS SQUIBB COMPANY | 2003-01-21 | — | — | US | disclosed |