Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 8/20 | 0.59 |
| ▸ | EGFR | P00533 | 7/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.57 |
| ▸ | IGF1R | P08069 | 6/20 | 0.51 |
| ▸ | SRC | P12931 | 3/20 | 0.47 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998072 | 0.88 | MAP2K1 (0.57) | MAP2K1EGFRERBB2IGF1RSRC | |
| SCHEMBL2202839 | 0.86 | MAP2K1 (0.69) | MAP2K1EGFRERBB2IGF1RSRC | |
| SCHEMBL7000818 | 0.85 | EGFR (0.55) | MAP2K1EGFRERBB2IGF1RSRC | |
| SCHEMBL7002118 | 0.83 | IGF1R (0.74) | MAP2K1EGFRERBB2IGF1RMAPK3 | |
| SCHEMBL2204296 | 0.81 | MAP2K1 (0.64) | MAP2K1EGFRERBB2IGF1RSRC | |
| SCHEMBL6383067 | 0.80 | EGFR (0.69) | EGFRERBB2SRC | |
| SCHEMBL6992590 | 0.76 | EGFR (0.55) | MAP2K1EGFRERBB2IGF1RSRC | |
| SCHEMBL7000625 | 0.76 | MAP2K1 (0.53) | MAP2K1EGFRERBB2IGF1R | |
| SCHEMBL6386083 | 0.76 | IGF1R (0.53) | MAP2K1EGFRERBB2IGF1RSRC | |
| SCHEMBL6999694 | 0.76 | MAP2K1 (0.52) | MAP2K1EGFRERBB2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | claimed |