Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.55 |
| ▸ | SRC | P12931 | 4/20 | 0.49 |
| ▸ | IGF1R | P08069 | 2/20 | 0.46 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.45 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
| ▸ | STK4 | Q13043 | 1/20 | 0.42 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7001573 | 0.88 | EGFR (0.55) | EGFRERBB2SRCIGF1RMAP3K8 | |
| SCHEMBL4447081 | 0.85 | EGFR (0.65) | EGFRERBB2SRCIGF1RMAP2K1 | |
| SCHEMBL6383067 | 0.82 | EGFR (0.69) | EGFRERBB2SRCMAP3K8 | |
| SCHEMBL4449025 | 0.80 | EGFR (0.63) | EGFRERBB2SRCIGF1RSTK4 | |
| SCHEMBL7002441 | 0.79 | EGFR (0.57) | EGFRERBB2SRCIGF1RMAP3K8 | |
| SCHEMBL7002118 | 0.79 | IGF1R (0.74) | EGFRERBB2IGF1RMAP2K1 | |
| SCHEMBL6999369 | 0.77 | EGFR (0.58) | EGFRERBB2SRCMAP3K8STK4 | |
| SCHEMBL6995338 | 0.76 | MAP2K1 (0.59) | EGFRERBB2SRCIGF1RMAP2K1 | |
| SCHEMBL6379771 | 0.75 | SRC (0.61) | EGFRERBB2SRCMAP3K8PRKCQ | |
| SCHEMBL6382251 | 0.75 | EGFR (0.54) | EGFRERBB2SRCMAP3K8MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | claimed |