Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 11/20 | 0.39 |
| ▸ | ERCC5 | P28715 | 8/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PKLR | P30613 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15204264 | 0.87 | FEN1 (0.38) | FEN1ERCC5PTGER4MCL1 | |
| SCHEMBL10164977 | 0.74 | ALDH1A1 (0.51) | FEN1KMT2A | |
| SCHEMBL10627660 | 0.68 | ALDH1A1 (0.51) | ERCC5KMT2A | |
| SCHEMBL617723 | 0.68 | MCL1 (0.36) | FEN1ERCC5PTGER4KMT2AMCL1 | |
| SCHEMBL3712434 | 0.68 | CYP2C9 (0.36) | KMT2APKMMCL1 | |
| SCHEMBL617325 | 0.67 | CHRM1 (0.44) | FEN1 | |
| SCHEMBL9980879 | 0.67 | PTGER4 (0.58) | PTGER4KMT2APKM | |
| SCHEMBL617722 | 0.67 | PTGDR2 (0.31) | KMT2AMCL1 | |
| SCHEMBL17024749 | 0.66 | HSD17B10 (0.40) | FEN1ERCC5KMT2A | |
| SCHEMBL13885836 | 0.65 | PTGER4 (0.64) | PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421366-B1 | HETEROCYCLIC FUSED CINNOLINE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2013-08-28 | — | — | EP | disclosed |
| US-8293744-B2 | Heterocyclic fused cinnoline M1 receptor positive allosteric modulators | MERCK SHARP & DOHME CORP. (US) | 2012-10-23 | — | — | US | disclosed |
| EP-2421366-A1 | HETEROCYCLIC FUSED CINNOLINE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck Sharp & Dohme Corp. (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010123716-A1 | HETEROCYCLIC FUSED CINNOLINE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-28 | — | — | WO | disclosed |