Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6995731 | 1.00 | PIM1 (0.44) | PIM1PIM2SLC6A4GSK3BHTR1D | |
| SCHEMBL7001453 | 0.85 | SLC6A4 (0.39) | SLC6A4 | |
| SCHEMBL7002581 | 0.85 | SLC6A4 (0.39) | SLC6A4 | |
| SCHEMBL7001456 | 0.85 | SLC6A4 (0.39) | SLC6A4 | |
| SCHEMBL7001003 | 0.83 | SLC6A4 (0.38) | SLC6A4 | |
| SCHEMBL7001276 | 0.82 | MAPK11 (0.46) | PIM1PIM2SLC6A4GSK3BHTR1D | |
| SCHEMBL7001275 | 0.82 | MAPK11 (0.46) | PIM1PIM2SLC6A4GSK3BHTR1D | |
| SCHEMBL7007803 | 0.80 | SLC6A4 (0.59) | SLC6A4 | |
| SCHEMBL7007800 | 0.80 | SLC6A4 (0.59) | SLC6A4 | |
| SCHEMBL6999439 | 0.79 | SLC6A4 (0.56) | SLC6A4HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562809-B1 | Contraction of coronary arteries may be mediated by its stimulation of the 5-HT1B (formerly 5-HT1D beta); compounds selective for a 5-HT1D receptor | NPS ALLELIX CORP. (CA) | 2003-05-13 | — | — | US | claimed |
| EP-1114049-B1 | 3-BICYCLOINDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | NPS ALLELIX CORP (CA) | 2003-03-19 | — | — | EP | claimed |
| US-6562809-B1 | Contraction of coronary arteries may be mediated by its stimulation of the 5-HT1B (formerly 5-HT1D beta); compounds selective for a 5-HT1D receptor | NPS ALLELIX CORP. (CA) | 2003-05-13 | — | — | US | disclosed |
| EP-1114049-B1 | 3-BICYCLOINDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | NPS ALLELIX CORP (CA) | 2003-03-19 | — | — | EP | disclosed |