Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.68 |
| ▸ | ERBB2 | P04626 | 11/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | ERBB4 | Q15303 | 4/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8487002 | 0.92 | EGFR (0.59) | EGFRERBB2HPGDHTTERBB4 | |
| SCHEMBL8485063 | 0.90 | EGFR (0.57) | EGFRERBB2HPGDHTTERBB4 | |
| SCHEMBL8522097 | 0.85 | EGFR (0.59) | EGFRERBB2HPGDHTTERBB4 | |
| SCHEMBL6993725 | 0.85 | EGFR (0.68) | EGFRERBB2HPGDHTTERBB4 | |
| SCHEMBL8317451 | 0.84 | EGFR (0.69) | EGFRERBB2HPGDHTTERBB4 | |
| SCHEMBL6997525 | 0.84 | EGFR (0.67) | EGFRERBB2HPGDHTTERBB4 | |
| SCHEMBL6991323 | 0.84 | EGFR (0.61) | EGFRERBB2HPGDHTTERBB4 | |
| SCHEMBL8315593 | 0.82 | EGFR (0.59) | EGFRERBB2HPGDHTTERBB4 | |
| SCHEMBL6986993 | 0.82 | EGFR (0.76) | EGFRERBB2HPGDHTTERBB4 | |
| SCHEMBL8319020 | 0.82 | EGFR (0.59) | EGFRERBB2HPGDHTTERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | disclosed |