Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CX3CR1 | P49238 | 9/20 | 0.42 |
| ▸ | CXCR2 | P25025 | 8/20 | 0.42 |
| ▸ | PAK4 | O96013 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6866077 | 0.89 | CXCR2 (0.51) | NPC1POLBRAB9ASMN1; SMN2CX3CR1 | |
| SCHEMBL6865674 | 0.83 | CXCR2 (0.62) | CX3CR1CXCR2 | |
| SCHEMBL6865997 | 0.83 | CXCR2 (0.61) | CX3CR1CXCR2ALDH1A1MEN1KMT2A | |
| SCHEMBL6859474 | 0.81 | PAK4 (0.53) | NPC1POLBRAB9ASMN1; SMN2CXCR2 | |
| SCHEMBL6868059 | 0.80 | CX3CR1 (0.63) | CX3CR1CXCR2 | |
| SCHEMBL6864151 | 0.80 | CX3CR1 (0.51) | NPC1POLBRAB9ASMN1; SMN2CX3CR1 | |
| SCHEMBL6869027 | 0.73 | CXCR2 (0.61) | CX3CR1CXCR2PAK4 | |
| SCHEMBL6999221 | 0.71 | CX3CR1 (0.46) | CX3CR1CXCR2PAK4TSHRNPSR1 | |
| SCHEMBL6866690 | 0.71 | CXCR2 (0.61) | CX3CR1CXCR2PAK4 | |
| SCHEMBL6864160 | 0.70 | CXCR2 (0.56) | CX3CR1CXCR2PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104425-B1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | claimed |