Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6996428 | 0.90 | BRAF (0.35) | BRAFMALT1CA1CA2CA7 | |
| SCHEMBL7002055 | 0.87 | PTGS2 (0.33) | BRAF | |
| SCHEMBL6994802 | 0.84 | PTGS2 (0.33) | BRAF | |
| SCHEMBL6996644 | 0.84 | PTGS2 (0.40) | BRAF | |
| SCHEMBL7002126 | 0.83 | BRAF (0.36) | BRAFMALT1CA1CA2CA7 | |
| SCHEMBL6994838 | 0.83 | PTGS2 (0.41) | BRAF | |
| SCHEMBL7002269 | 0.82 | BRAF (0.41) | BRAFCA1CA2CA7CA9 | |
| SCHEMBL6994747 | 0.81 | BRAF (0.37) | BRAFMALT1CA1CA2CA7 | |
| SCHEMBL6992401 | 0.81 | BRAF (0.37) | BRAF | |
| SCHEMBL6999198 | 0.80 | PTGS2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | claimed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | claimed |
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | disclosed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | disclosed |