Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.44 |
| ▸ | PREP | P48147 | 8/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | F3 | P13726 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5801831 | 0.83 | ACE (0.39) | ACEPREPF2F7F3 | |
| SCHEMBL5748164 | 0.83 | ACE (0.39) | ACEPREPF2F7F3 | |
| SCHEMBL5748168 | 0.80 | ACE (0.39) | ACEPREPF2F7F3 | |
| SCHEMBL5801832 | 0.80 | ACE (0.39) | ACEPREPF2F7F3 | |
| SCHEMBL5729773 | 0.80 | F7 (0.58) | ACEF2F7F3 | |
| SCHEMBL31486289 | 0.80 | F7 (0.58) | ACEF2F7F3 | |
| SCHEMBL31565049 | 0.77 | FKBP1A (0.47) | PREPF2F7F3 | |
| SCHEMBL31486297 | 0.77 | FKBP1A (0.47) | PREPF2F7F3 | |
| SCHEMBL31486250 | 0.75 | ACE (0.39) | ACEPREPF2F7F3 | |
| SCHEMBL31486229 | 0.75 | PREP (0.51) | ACEPREPF2F7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069132-B1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | SERVIER LAB (FR) | 2003-10-01 | — | — | EP | disclosed |
| US-6277851-B1 | ORALLY ADMINISTERED TRYPSIN-RELATED SERINE PROTEASE INHIBITORS; ANTICOAGULANTS | ADIR ET COMPAGNIE (FR) | 2001-08-21 | — | — | US | disclosed |
| EP-1069132-A1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | ADIR ET COMPAGNIE (FR) | 2001-01-17 | — | — | EP | disclosed |