Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 3/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.37 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.37 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3459528 | 0.75 | BCHE (0.48) | BCHEMAPK1HDAC1HDAC6GPR119 | |
| SCHEMBL5670700 | 0.72 | BCHE (0.46) | BCHEMAPK1HDAC1HDAC6GPR119 | |
| SCHEMBL29479856 | 0.71 | BCHE (0.62) | BCHEMAPK1GPR119NAMPTKDM1A | |
| SCHEMBL507146 | 0.69 | NR1H2 (0.61) | MAPK1GPR119NAMPTCHRM2CHRM4 | |
| SCHEMBL17276765 | 0.69 | CKS1B (0.55) | BCHEGPR119NAMPTMEN1KMT2A | |
| SCHEMBL30900483 | 0.69 | NOTUM (0.61) | KDM1AMEN1KMT2APOLB | |
| SCHEMBL552069 | 0.69 | NOTUM (0.61) | KDM1AMEN1KMT2APOLB | |
| SCHEMBL14587287 | 0.69 | KDM1A (0.46) | BCHEMAPK1HDAC1HDAC6GPR119 | |
| SCHEMBL6204851 | 0.68 | MAPK1 (0.52) | BCHEMAPK1HDAC1GPR119NAMPT | |
| SCHEMBL5183098 | 0.68 | MAPK1 (0.64) | MAPK1HDAC1GPR119NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351946-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2003-10-15 | — | — | EP | claimed |
| WO-2002020500-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2002-03-14 | — | — | WO | claimed |