Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KDM1A | O60341 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30900483 | 1.00 | NOTUM (0.61) | NOTUMRAB9ANPC1L3MBTL1TSHR | |
| SCHEMBL3127747 | 0.91 | NOTUM (0.63) | NOTUMTSHRALDH1A1MAPTHPGD | |
| SCHEMBL29476005 | 0.91 | NOTUM (0.63) | NOTUMTSHRALDH1A1MAPTHPGD | |
| SCHEMBL5795681 | 0.90 | NOTUM (0.57) | NOTUMTSHRALDH1A1KMT2AMEN1 | |
| SCHEMBL20832607 | 0.85 | RAB9A (0.56) | NOTUMRAB9ANPC1L3MBTL1TSHR | |
| SCHEMBL5806132 | 0.85 | NOTUM (0.58) | NOTUMRAB9ANPC1TSHRALDH1A1 | |
| SCHEMBL30721522 | 0.82 | NOTUM (0.67) | NOTUMRAB9ANPC1L3MBTL1TSHR | |
| SCHEMBL5585204 | 0.82 | NOTUM (0.67) | NOTUMRAB9ANPC1L3MBTL1TSHR | |
| SCHEMBL21285908 | 0.81 | KDM1A (0.53) | NOTUMTSHRALDH1A1KDM1A | |
| SCHEMBL27620869 | 0.81 | ALDH1A1 (0.57) | NOTUMRAB9ANPC1L3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 195 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115353478-A | Preparation method of indole compound | 南京工业大学 | 2022-11-18 | — | — | CN | claimed |
| CN-107098845-A | A kind of preparation technology of the nitroindoline of 5 cyano group 6 | 贵州大学 | 2017-08-29 | — | — | CN | claimed |
| US-12422399-B2 | Systems, devices, and methods for gas sensing | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2025-09-23 | — | — | US | disclosed |
| US-12365681-B2 | Dihydrobenzimidazolones for medical treatment | C4 THERAPEUTICS, INC. (US) | 2025-07-22 | — | — | US | disclosed |
| CN-120077040-A | Compounds for SHP2 protein degradation and medical uses thereof | 尤比克斯治疗公司 | 2025-05-30 | — | — | CN | disclosed |
| CN-119255997-A | Modulators of c-MYC mRNA translation and their use in the treatment of cancer | 艾尼莫生物科技公司 | 2025-01-03 | — | — | CN | disclosed |
| US-20240353369-A1 | SYSTEMS, DEVICES, AND METHODS FOR GAS SENSING | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2024-10-24 | — | — | US | disclosed |
| CN-114380799-B | COT modulators and methods of use thereof | 吉利德科学公司 | 2024-10-01 | — | — | CN | disclosed |
| US-12013367-B2 | Monolithic 3D integrated circuit for gas sensing and method of making and system using | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2024-06-18 | — | — | US | disclosed |
| CN-117917406-A | Heterocyclic compounds, process for their preparation and their use | 四川科伦博泰生物医药股份有限公司 | 2024-04-23 | — | — | CN | disclosed |
| US-20240109889-A1 | DIHYDROBENZIMIDAZOLONES FOR MEDICAL TREATMENT | C4 THERAPEUTICS, INC. (US) | 2024-04-04 | — | — | US | disclosed |
| EP-1399445-A2 | SUBSTITUTED PYRROLOQUINOLINES AND PYRIDOQUINOLINES AS SEROTONIN AGONISTS AND ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-03-24 | — | — | EP | disclosed |
| US-6630496-B1 | Antiinflammatory agents inhibit phospholipase 2, affecting both protaglandin and leukotriene production; indoles substituted in 2 position by 2,4-dioxo-thiazol-3-yl methylidene | GENETICS INSTITUTE LLC | 2003-10-07 | — | — | US | disclosed |
| WO-2002059124-A2 | SUBSTITUTED PYRROLOQUINOLINES AND PYRIDOQUINOLINES AS SEROTONIN AGONISTS AND ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-08-01 | — | — | WO | disclosed |
| EP-1062216-A1 | INHIBITORS OF PHOSPHOLIPASE A2 | GENETICS INSTITUTE, INC. (US) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999043672-A9 | INHIBITORS OF PHOSPHOLIPASE A2 | GENETICS INST (US) | 2000-05-04 | — | — | WO | disclosed |
| WO-1999043672-A1 | INHIBITORS OF PHOSPHOLIPASE A2 | GENETICS INSTITUTE, INC. (US) | 1999-09-02 | — | — | WO | disclosed |
| EP-0922028-A1 | INHIBITORS OF PHOSPHOLIPASE ENZYMES | GENETICS INSTITUTE, INC. (US) | 1999-06-16 | — | — | EP | disclosed |
| CN-1214690-A | Specific immunophilin ligands as antiasthmatics and immunosuppressants | ASTA MEDICA AG (DE) | 1999-04-21 | — | — | CN | disclosed |
| WO-1998008818-A1 | INHIBITORS OF PHOSPHOLIPASE ENZYMES | GENETICS INSTITUTE, INC. (US) | 1998-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12365681-B2 | Dihydrobenzimidazolones for medical treatment | CRBN, CUL4A, ADRM1 | NOTUM 4088/4885RAB9A 3519/4885NPC1 3010/4885 |
| US-20240109889-A1 | DIHYDROBENZIMIDAZOLONES FOR MEDICAL TREATMENT | CRBN, CUL4A, ADRM1 | NOTUM 4088/4885RAB9A 3519/4885NPC1 3010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.