Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HTR5A | P47898 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ILK | Q13418 | 1/20 | 0.31 |
| ▸ | BCKDK | O14874 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7000443 | 0.92 | SMN1; SMN2 (0.37) | AXLGFERALDH1A1ILK | |
| SCHEMBL6998543 | 0.90 | BACE1 (0.35) | AXLGFERMAPTHTR5AALDH1A1 | |
| SCHEMBL4836633 | 0.90 | MAPT (0.34) | AXLGFERMAPTHTR5AALDH1A1 | |
| Hydrochloric Acid SCHEMBL4843553 | 0.89 | MAPT (0.34) | MAPTHTR5AALDH1A1 | |
| SCHEMBL6995079 | 0.89 | MAPT (0.42) | MAPTALDH1A1LMNAPOLBILK | |
| Hydrochloric Acid SCHEMBL4843547 | 0.88 | MAPT (0.35) | MAPTALDH1A1 | |
| SCHEMBL6994128 | 0.80 | IDO1 (0.34) | MAPTALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL4843411 | 0.79 | IDO1 (0.33) | MAPTALDH1A1POLB | |
| SCHEMBL6998645 | 0.76 | CHRM1 (0.49) | GFERHTR5ALMNA | |
| SCHEMBL4844178 | 0.75 | BACE1 (0.35) | MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1016664-B1 | FUSED THIOPHENE COMPOUNDS AND MEDICINAL USE THEREOF | MITSUBISHI PHARMA CORP (JP) | 2003-07-02 | — | — | EP | disclosed |
| US-6455521-B1 | PSYCHOLOGICAL DISORDERS; SIDE EFFECT REDUCTION | MITSUBISHI PHARMA CORPORATION (JP) | 2002-09-24 | — | — | US | disclosed |
| EP-1016664-A1 | FUSED THIOPHENE COMPOUNDS AND MEDICINAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2000-07-05 | — | — | EP | disclosed |