Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 2/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.32 |
| ▸ | DRD2 | P14416 | 4/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.32 |
| ▸ | DRD1 | P21728 | 4/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.32 |
| ▸ | HTR2A | P28223 | 4/20 | 0.32 |
| ▸ | HTR2C | P28335 | 4/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.32 |
| ▸ | HRH1 | P35367 | 4/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.32 |
| ▸ | HTR2B | P41595 | 4/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6996940 | 0.90 | AXL (0.34) | GFERAXLLMNAHTR5AALDH1A1 | |
| SCHEMBL7001273 | 0.85 | DRD2 (0.35) | GFERLMNACHRM2CHRM4CHRM5 | |
| SCHEMBL6994128 | 0.85 | IDO1 (0.34) | BACE1CHRM1HRH1MEN1KMT2A | |
| SCHEMBL4836633 | 0.85 | MAPT (0.34) | BACE1GFERAXLHTR5ASMN1; SMN2 | |
| SCHEMBL7000443 | 0.84 | SMN1; SMN2 (0.37) | GFERAXLGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL14156629 | 0.84 | LMNA (0.36) | BACE1GFERLMNACHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL4843411 | 0.84 | IDO1 (0.33) | BACE1CHRM1HRH1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4843553 | 0.84 | MAPT (0.34) | BACE1HTR5ASMN1; SMN2ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL4843547 | 0.83 | MAPT (0.35) | BACE1SMN1; SMN2ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL4836312 | 0.83 | LMNA (0.35) | BACE1GFERLMNACHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1016664-B1 | FUSED THIOPHENE COMPOUNDS AND MEDICINAL USE THEREOF | MITSUBISHI PHARMA CORP (JP) | 2003-07-02 | — | — | EP | disclosed |
| US-6455521-B1 | PSYCHOLOGICAL DISORDERS; SIDE EFFECT REDUCTION | MITSUBISHI PHARMA CORPORATION (JP) | 2002-09-24 | — | — | US | disclosed |
| EP-1016664-A1 | FUSED THIOPHENE COMPOUNDS AND MEDICINAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2000-07-05 | — | — | EP | disclosed |