Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 16/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 16/20 | 0.52 |
| ▸ | CDK2 | P24941 | 16/20 | 0.52 |
| ▸ | CDK4 | P11802 | 12/20 | 0.52 |
| ▸ | CCND1 | P24385 | 12/20 | 0.52 |
| ▸ | CCNB2 | O95067 | 10/20 | 0.52 |
| ▸ | CDK1 | P06493 | 10/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 10/20 | 0.52 |
| ▸ | CCNB3 | Q8WWL7 | 10/20 | 0.52 |
| ▸ | PDE2A | O00408 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997368 | 0.95 | CCNE2 (0.51) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL6999184 | 0.90 | PDE2A (0.57) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL6987648 | 0.90 | PDE2A (0.47) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL6998938 | 0.88 | CCNE2 (0.44) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL6991547 | 0.87 | PDE2A (0.49) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL6998132 | 0.87 | CCNE2 (0.43) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL6998944 | 0.84 | CCNE2 (0.54) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL7892404 | 0.82 | CCNE2 (0.53) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL6996492 | 0.81 | PDE2A (0.47) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL4947310 | 0.80 | PDE2A (0.62) | CCNE2CCNE1CDK2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973774-B1 | 1,5-DIHYDRO-PYRAZOLO 3,4-D]-PYRIMIDINONE DERIVATIVES | BAYER AG (DE) | 2003-01-22 | — | — | EP | disclosed |
| US-6174884-B1 | CARDIOVASCULAR DISORDERS; CEREBROVASCULAR DISEASES; VASCULAR SYSTEM DISORDERS, ESPECIALLY THE PERIPHERAL BLOOD VESSELS; UROGENITAL DISORDERS; HYPOTENSIVE AGENTS; ANTIARRYTHMIA AND -ISCHEMIC AGENTS; PHOSPHODIESTERASE ACTIVITY | BAYER AKTIENGESELLSCHAFT (DE) | 2001-01-16 | — | — | US | disclosed |