Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.69 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.69 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.69 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.69 |
| ▸ | TTR | P02766 | 1/20 | 0.69 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 13/20 | 0.65 |
| ▸ | MEN1 | O00255 | 7/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.63 |
| ▸ | GAA | P10253 | 6/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | APAF1 | O14727 | 1/20 | 0.63 |
| ▸ | CASP6 | P55212 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2738213 | 0.90 | CTNNB1 (0.78) | PIK3CDPIK3CAPIK3CBPIK3CGCTNNB1 | |
| SCHEMBL6997212 | 0.88 | CTNNB1 (0.65) | PIK3CDPIK3CAPIK3CBPIK3CGTTR | |
| SCHEMBL1792865 | 0.88 | CTNNB1 (0.86) | PIK3CDPIK3CAPIK3CBPIK3CGTTR | |
| SCHEMBL1788590 | 0.88 | APAF1 (0.81) | PIK3CDPIK3CAPIK3CBPIK3CGTTR | |
| SCHEMBL1791652 | 0.88 | TTR (0.81) | PIK3CDPIK3CAPIK3CBPIK3CGTTR | |
| SCHEMBL1793277 | 0.87 | MAPT (0.77) | PIK3CDPIK3CAPIK3CBPIK3CGTTR | |
| SCHEMBL1789260 | 0.86 | MAPT (0.77) | PIK3CDPIK3CAPIK3CBPIK3CGTTR | |
| SCHEMBL1789298 | 0.86 | MAPT (0.76) | PIK3CDPIK3CAPIK3CBPIK3CGTTR | |
| SCHEMBL1792556 | 0.86 | PIK3CD (0.72) | PIK3CDPIK3CAPIK3CBPIK3CGTTR | |
| SCHEMBL1788909 | 0.84 | PIK3CD (0.70) | PIK3CDPIK3CAPIK3CBPIK3CGTTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012065057-A2 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS AND METHODS OF THEIR USE | EXELIXIS, INC. (US) | 2012-05-18 | — | — | WO | disclosed |
| WO-2008127594-A2 | COMBINATION THERAPIES COMPRISING QUINOXALINE INHIBITORS OF PI3K-ALPHA FOR USE IN THE TREATMENT OF CANCER | EXELIXIS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |