Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | PRCP | P42785 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.50 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6999017 | 0.98 | OPRM1 (0.51) | SIGMAR1GRIN1GRIN2AGRIN2BSLC6A3 | |
| SCHEMBL6994482 | 0.74 | GRIN1 (0.40) | SIGMAR1GRIN1GRIN2AGRIN2BSLC6A3 | |
| SCHEMBL6992429 | 0.74 | GRIN1 (0.40) | SIGMAR1GRIN1GRIN2AGRIN2BSLC6A3 | |
| SCHEMBL6998974 | 0.74 | GRIN1 (0.40) | SIGMAR1GRIN1GRIN2AGRIN2BSLC6A3 | |
| SCHEMBL6995762 | 0.74 | GRIN1 (0.40) | SIGMAR1GRIN1GRIN2AGRIN2BSLC6A3 | |
| SCHEMBL6992113 | 0.74 | GRIN1 (0.42) | SIGMAR1GRIN1GRIN2AGRIN2BSLC6A3 | |
| Hydrochloric Acid SCHEMBL6997379 | 0.73 | OPRM1 (0.41) | SIGMAR1GRIN1GRIN2AGRIN2BSLC6A3 | |
| Hydrochloric Acid SCHEMBL6993575 | 0.73 | OPRM1 (0.41) | SIGMAR1GRIN1GRIN2AGRIN2BSLC6A3 | |
| Hydrochloric Acid SCHEMBL6999005 | 0.73 | OPRM1 (0.41) | SIGMAR1GRIN1GRIN2AGRIN2BSLC6A3 | |
| Hydrochloric Acid SCHEMBL6995633 | 0.73 | OPRM1 (0.41) | SIGMAR1GRIN1GRIN2AGRIN2BSLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970083-B1 | 7a-HETEROCYCLE-SUBSTITUTED HEXAHYDRO-1H-PYRROLIZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2003-04-16 | — | — | EP | claimed |
| EP-0970083-B1 | 7a-HETEROCYCLE-SUBSTITUTED HEXAHYDRO-1H-PYRROLIZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2003-04-16 | — | — | EP | disclosed |
| EP-0970083-A1 | 7a-HETEROCYCLE-SUBSTITUTED HEXAHYDRO-1H-PYRROLIZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998037082-A1 | 7a-HETEROCYCLE-SUBSTITUTED HEXAHYDRO-1H-PYRROLIZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1998-08-27 | — | — | WO | disclosed |
| US-5733912-A | NERVOUS SYSTEM DISORDERS IN NERVE CELLS | ABBOTT LABORATORIES (US) | 1998-03-31 | — | — | US | disclosed |