Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 5/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | AGER | Q15109 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6743187 | 0.91 | GRIN1 (0.40) | GRIN1GRIN2BMEN1KMT2AKDM1A | |
| SCHEMBL6622630 | 0.88 | MEN1 (0.53) | GRIN1GRIN2BMEN1KMT2AKCNH2 | |
| SCHEMBL6619543 | 0.88 | MEN1 (0.53) | GRIN1GRIN2BMEN1KMT2AKCNH2 | |
| SCHEMBL6317973 | 0.87 | GRIN1 (0.40) | GRIN1GRIN2BMEN1KMT2AKDM1A | |
| SCHEMBL6738989 | 0.87 | DPP4 (0.41) | GRIN1GRIN2BMEN1KMT2AKDM1A | |
| SCHEMBL6614408 | 0.86 | GPR119 (0.46) | GRIN1GRIN2BKDM1AKCNH2 | |
| SCHEMBL6733487 | 0.86 | CHRNA7 (0.40) | GRIN1GRIN2BKDM1AKCNH2MMP2 | |
| SCHEMBL6738018 | 0.85 | KCNH2 (0.39) | GRIN1GRIN2BMEN1KMT2AKDM1A | |
| SCHEMBL6997502 | 0.85 | KCNH2 (0.46) | GRIN1GRIN2BMEN1KMT2AKCNH2 | |
| SCHEMBL6995039 | 0.83 | GRIN1 (0.42) | GRIN1GRIN2BMEN1KMT2AKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192154-B1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2004-03-17 | — | — | EP | claimed |
| US-6887881-B1 | Bispidine compounds useful in the treatment of cardiac arrythmias | ASTRAZENECA AB (SE) | 2005-05-03 | — | — | US | disclosed |
| EP-1192154-B1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2004-03-17 | — | — | EP | disclosed |
| EP-1192154-A1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076999-A1 | NEW BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | disclosed |