Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | APAF1 | O14727 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 5/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.45 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 3/20 | 0.44 |
| ▸ | STK4 | Q13043 | 7/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7003243 | 0.95 | MAPT (0.48) | MAPTALDH1A1MEN1CYP1A2CYP3A4 | |
| SCHEMBL6998133 | 0.88 | PRKCQ (0.49) | MAPTALDH1A1HTTKDM4EEGFR | |
| SCHEMBL6994510 | 0.87 | PRKCQ (0.51) | EGFRERBB2SRC | |
| SCHEMBL7000645 | 0.87 | EGFR (0.51) | MAPTALDH1A1HTTKDM4EEGFR | |
| SCHEMBL6999119 | 0.85 | SRC (0.43) | MAPTALDH1A1HTTKDM4EEGFR | |
| SCHEMBL7000865 | 0.85 | SRC (0.43) | MAPTALDH1A1HTTKDM4EEGFR | |
| SCHEMBL4450594 | 0.84 | EGFR (0.64) | EGFRERBB2SRCSTK4 | |
| SCHEMBL7004154 | 0.84 | SRC (0.49) | MAPTALDH1A1HTTKDM4EEGFR | |
| SCHEMBL6999325 | 0.82 | SRC (0.54) | SRC | |
| SCHEMBL6997390 | 0.82 | SRC (0.41) | MAPTALDH1A1HTTKDM4EEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | claimed |