Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.56 |
| ▸ | DHODH | Q02127 | 1/20 | 0.56 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MASP2 | O00187 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.51 |
| ▸ | CFD | P00746 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13936398 | 0.83 | DHODH (0.64) | KMT2AABCC1DHODHTRPM8KDM4E | |
| SCHEMBL10144304 | 0.83 | KDM4E (0.74) | KMT2AABCC1DHODHTRPM8KDM4E | |
| SCHEMBL29543730 | 0.82 | KMT2A (0.70) | KMT2AABCC1KDM4EPOLBCYP2C9 | |
| SCHEMBL111479 | 0.82 | KMT2A (0.70) | KMT2AABCC1KDM4EPOLBCYP2C9 | |
| SCHEMBL6539763 | 0.82 | KMT2A (0.53) | KMT2AABCC1DHODHTRPM8KDM4E | |
| SCHEMBL30583240 | 0.80 | PTPN1 (0.64) | KMT2ADHODHTRPM8POLBMASP2 | |
| SCHEMBL4315667 | 0.80 | PTPN1 (0.64) | KMT2ADHODHTRPM8POLBMASP2 | |
| SCHEMBL6997874 | 0.79 | GPR35 (0.63) | KMT2AABCC1DHODHTRPM8KDM4E | |
| Phenol SCHEMBL28121926 | 0.78 | KMT2A (0.64) | KMT2AABCC1KDM4EPOLBCYP2C9 | |
| SCHEMBL346345 | 0.77 | DHODH (0.62) | KMT2AABCC1DHODHTRPM8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0980374-B1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PFIZER HOLDING FRANCE (FR) | 2003-02-12 | — | — | EP | disclosed |
| US-6239130-B1 | ASTHMA, ATOPIC DERMATITIS, RHEUMATOID ARTHRITIS, INFLAMMATORY BOWEL DISORDERS, PULMONARY HYPERTENSION, LIVER INJURY, BONE LOSS, SEPTIC SHOCK, OR MULTIPLE SCLEROSIS, | WARNER-LAMBERT COMPANY | 2001-05-29 | — | — | US | disclosed |
| EP-0980374-A1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PARKE-DAVIS (FR) | 2000-02-23 | — | — | EP | disclosed |
| WO-1998049169-A1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PARKE-DAVIS (FR) | 1998-11-05 | — | — | WO | disclosed |