Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.41 |
| ▸ | NOS1 | P29475 | 4/20 | 0.39 |
| ▸ | NOS3 | P29474 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997685 | 0.91 | SLC6A4 (0.36) | SLC6A4NOS1NOS3NOS2 | |
| SCHEMBL7002561 | 0.91 | SLC6A4 (0.36) | SLC6A4NOS1NOS3NOS2 | |
| SCHEMBL6999590 | 0.89 | SLC6A4 (0.35) | SLC6A4NOS1NOS3NOS2 | |
| SCHEMBL7006099 | 0.81 | SLC6A4 (0.53) | SLC6A4NOS1NOS3NOS2 | |
| SCHEMBL7010984 | 0.81 | SLC6A4 (0.53) | SLC6A4NOS1NOS3NOS2 | |
| SCHEMBL6999444 | 0.81 | SLC6A4 (0.56) | SLC6A4 | |
| SCHEMBL6999439 | 0.81 | SLC6A4 (0.56) | SLC6A4 | |
| SCHEMBL6965518 | 0.80 | SLC6A4 (0.65) | SLC6A4 | |
| SCHEMBL1122232 | 0.78 | HTR1D (0.43) | SLC6A4NOS1NOS3NOS2 | |
| SCHEMBL6994351 | 0.78 | SLC6A4 (0.56) | SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562809-B1 | Contraction of coronary arteries may be mediated by its stimulation of the 5-HT1B (formerly 5-HT1D beta); compounds selective for a 5-HT1D receptor | NPS ALLELIX CORP. (CA) | 2003-05-13 | — | — | US | claimed |
| EP-1114049-B1 | 3-BICYCLOINDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | NPS ALLELIX CORP (CA) | 2003-03-19 | — | — | EP | claimed |
| US-6562809-B1 | Contraction of coronary arteries may be mediated by its stimulation of the 5-HT1B (formerly 5-HT1D beta); compounds selective for a 5-HT1D receptor | NPS ALLELIX CORP. (CA) | 2003-05-13 | — | — | US | disclosed |
| EP-1114049-B1 | 3-BICYCLOINDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | NPS ALLELIX CORP (CA) | 2003-03-19 | — | — | EP | disclosed |
| EP-1114049-A1 | 3-BICYCLOINDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | NPS Allelix Corp. (CA) | 2001-07-11 | — | — | EP | disclosed |
| WO-2000017198-A1 | 3-BICYCLOINDOLE COMPOUNDS AS 5-HT1D LIGANDS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-03-30 | — | — | WO | disclosed |