Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 2/20 | 0.73 |
| ▸ | IGF1R | P08069 | 13/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7000025 | 0.94 | FYN (0.65) | FYNIGF1RIKBKBAXLSRC | |
| SCHEMBL6996250 | 0.92 | FYN (0.70) | FYNIGF1RIKBKBSRC | |
| SCHEMBL6999961 | 0.90 | FYN (0.60) | FYNIGF1RIKBKBAXLSRC | |
| Hydrochloric Acid SCHEMBL6995021 | 0.90 | FYN (0.60) | FYNIGF1R | |
| SCHEMBL6995009 | 0.89 | FYN (0.57) | FYNIGF1RIKBKBAXLSRC | |
| SCHEMBL6991674 | 0.88 | FYN (0.57) | FYNIGF1R | |
| SCHEMBL6996576 | 0.86 | IGF1R (0.55) | FYNIGF1RAXL | |
| SCHEMBL7000248 | 0.85 | FYN (0.60) | FYNIGF1RIKBKBAXL | |
| SCHEMBL6994890 | 0.85 | FYN (0.60) | FYNIGF1RIKBKBAXL | |
| SCHEMBL20485699 | 0.85 | FYN (1.00) | FYNIGF1RIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0989985-B1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-11-05 | — | — | EP | disclosed |
| US-6133257-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-10-17 | — | — | US | disclosed |