Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 13/20 | 0.55 |
| ▸ | FYN | P06241 | 2/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.52 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | PLK1 | P53350 | 1/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.51 |
| ▸ | AXL | P30530 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7001192 | 0.92 | SYK (0.54) | IGF1RFYNCCNA2CDK2CDK5 | |
| SCHEMBL6995009 | 0.91 | FYN (0.57) | IGF1RFYNKDRAXL | |
| SCHEMBL6996684 | 0.88 | FYN (0.69) | IGF1RFYNCCNA2CDK2CDK5 | |
| SCHEMBL6994890 | 0.87 | FYN (0.60) | IGF1RFYNAXL | |
| SCHEMBL7000248 | 0.87 | FYN (0.60) | IGF1RFYNAXL | |
| SCHEMBL17560321 | 0.87 | KDR (0.64) | IGF1RFYNCCNA2CDK2CDK5 | |
| Hydrochloric Acid SCHEMBL6997962 | 0.87 | FYN (0.68) | IGF1RFYNCCNA2CDK2CDK5 | |
| SCHEMBL6997980 | 0.86 | FYN (0.73) | IGF1RFYNAXL | |
| Hydrochloric Acid SCHEMBL6995021 | 0.85 | FYN (0.60) | IGF1RFYN | |
| SCHEMBL6999961 | 0.85 | FYN (0.60) | IGF1RFYNKDRAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0989985-B1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-11-05 | — | — | EP | disclosed |
| US-6133257-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-10-17 | — | — | US | disclosed |