Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | BCR | P11274 | 2/20 | 0.43 |
| ▸ | PRKCA | P17252 | 2/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCND2 | P30279 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990925 | 0.91 | SYK (0.48) | EGFRBRAFPIM1SYK | |
| SCHEMBL6996349 | 0.83 | EGFR (0.48) | EGFRDYRK3MAP4K4PDGFRALTK | |
| SCHEMBL6992546 | 0.83 | EGFR (0.45) | EGFRABL1BCRPRKCACCNB2 | |
| SCHEMBL6992205 | 0.81 | EGFR (0.45) | EGFRABL1BCRPRKCACCNB2 | |
| SCHEMBL6996923 | 0.80 | EGFR (0.45) | EGFRDYRK3MAP4K4PDGFRALTK | |
| SCHEMBL6997797 | 0.80 | EGFR (0.67) | EGFR | |
| SCHEMBL6409884 | 0.78 | EGFR (0.62) | EGFRABL1PIM1MAP4K4LTK | |
| SCHEMBL6991965 | 0.76 | EGFR (0.48) | EGFRSYK | |
| SCHEMBL6999037 | 0.76 | EGFR (0.51) | EGFRABL1BCRFGFR2CDK2 | |
| SCHEMBL6999413 | 0.76 | ABCG2 (0.54) | EGFRSYKDYRK1AABCG2DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | disclosed |