Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.51 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.51 |
| ▸ | DRD1 | P21728 | 5/20 | 0.49 |
| ▸ | HTR2C | P28335 | 4/20 | 0.49 |
| ▸ | HRH1 | P35367 | 4/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.49 |
| ▸ | HTR2B | P41595 | 4/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 3/20 | 0.43 |
| ▸ | HRH2 | P25021 | 3/20 | 0.43 |
| ▸ | HTR1D | P28221 | 3/20 | 0.43 |
| ▸ | HTR1B | P28222 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | HTR7 | P34969 | 3/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998747 | 0.91 | DRD1 (0.43) | HTR2AGRM2DRD1ADRA1BTMEM97 | |
| SCHEMBL6998755 | 0.91 | DRD1 (0.43) | HTR2AGRM2DRD1ADRA1BTMEM97 | |
| SCHEMBL6998751 | 0.91 | DRD1 (0.43) | HTR2AGRM2DRD1ADRA1BTMEM97 | |
| SCHEMBL7001096 | 0.90 | HTR2A (0.49) | HTR2AGRM2DRD1HTR2CHRH1 | |
| SCHEMBL6992748 | 0.84 | DRD1 (0.63) | HTR2AGRM2DRD1ADRA1BADRA2B | |
| Bromide SCHEMBL6998756 | 0.83 | DRD1 (0.62) | HTR2AGRM2DRD1ADRA1BADRA2B | |
| SCHEMBL6992458 | 0.82 | DRD1 (0.42) | HTR2AGRM2DRD1HTR2CHRH1 | |
| SCHEMBL6998880 | 0.82 | DRD1 (0.41) | HTR2AGRM2DRD1ADRA1BTMEM97 | |
| SCHEMBL6998873 | 0.82 | DRD1 (0.41) | HTR2AGRM2DRD1ADRA1BTMEM97 | |
| SCHEMBL6998889 | 0.82 | DRD1 (0.41) | HTR2AGRM2DRD1ADRA1BTMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015446-B1 | (4-PIPERIDINYL)-1H-2-BENZOPYRAN DERIVATIVES USEFUL AS ANTIPSYCHOTIC AGENTS | AVENTIS PHARMA INC (US) | 2003-04-02 | — | — | EP | disclosed |
| US-6004982-A | SIDE EFFECT REDUCTION; SCHIZOPHRENIA | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |