Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 3/20 | 0.42 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7001481 | 0.84 | DRD1 (0.63) | DRD1HTR2CADRA2BADRA2CADRA1A | |
| SCHEMBL6998092 | 0.82 | HTR2A (0.51) | DRD1KCNH2HTR2AHTR2CHTR2B | |
| SCHEMBL6998755 | 0.75 | DRD1 (0.43) | DRD1HTR2AADRA1AGRM2 | |
| SCHEMBL6998747 | 0.75 | DRD1 (0.43) | DRD1HTR2AADRA1AGRM2 | |
| SCHEMBL6998751 | 0.75 | DRD1 (0.43) | DRD1HTR2AADRA1AGRM2 | |
| SCHEMBL6998063 | 0.73 | L3MBTL1 (0.37) | HTR2ADRD3LMNACNR1HTT | |
| SCHEMBL6998050 | 0.73 | L3MBTL1 (0.37) | HTR2ADRD3LMNACNR1HTT | |
| SCHEMBL6998054 | 0.73 | L3MBTL1 (0.37) | HTR2ADRD3LMNACNR1HTT | |
| SCHEMBL7001096 | 0.73 | HTR2A (0.49) | DRD1KCNH2HTR2AHTR2CHTR2B | |
| SCHEMBL6999111 | 0.71 | L3MBTL1 (0.40) | DRD1HTR2AHTR2CDRD3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015446-B1 | (4-PIPERIDINYL)-1H-2-BENZOPYRAN DERIVATIVES USEFUL AS ANTIPSYCHOTIC AGENTS | AVENTIS PHARMA INC (US) | 2003-04-02 | — | — | EP | claimed |
| EP-1015446-A1 | (4-PIPERIDINYL)-1H-2-BENZOPYRAN DERIVATIVES USEFUL AS ANTIPSYCHOTIC AGENTS | Aventis Pharmaceuticals Inc. (US) | 2000-07-05 | — | — | EP | claimed |
| US-6004982-A | SIDE EFFECT REDUCTION; SCHIZOPHRENIA | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | claimed |
| WO-1998034933-A1 | (4-PIPERIDINYL)-1H-2-BENZOPYRAN DERIVATIVES USEFUL AS ANTIPSYCHOTIC AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1998-08-13 | — | — | WO | claimed |