SCHEMBL6998342

SCHEMBL6998342

CC1Oc2ccc(C(CC3CCCCC3)NC(=O)OC(C)(C)C)cc2NC1=O

nearest known ligand 0.40

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SMYD3 Q9H7B4 4/20 0.40
HSD17B1 P14061 1/20 0.39
HSD17B2 P37059 1/20 0.39
CTSS P25774 1/20 0.39
CTSK P43235 1/20 0.39
IDO1 P14902 1/20 0.38
TSHR P16473 1/20 0.38
PARP1 P09874 6/20 0.38
PDE3B Q13370 2/20 0.36
PDE3A Q14432 2/20 0.36
AAK1 Q2M2I8 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7711316 0.90 CTSS (0.38) HSD17B1HSD17B2CTSSCTSKIDO1
SCHEMBL7713374 0.82 PARP1 (0.50) CTSSCTSKIDO1TSHRPARP1
SCHEMBL7713294 0.81 PARP1 (0.42) SMYD3IDO1TSHRPARP1
SCHEMBL6302681 0.81 MAPT (0.40) SMYD3IDO1PARP1
SCHEMBL7713338 0.80 PARP1 (0.42) SMYD3IDO1TSHRPARP1
SCHEMBL7708144 0.80 PARP1 (0.42) SMYD3CTSSCTSKIDO1TSHR
SCHEMBL7710382 0.80 PARP1 (0.40) SMYD3PARP1
SCHEMBL7711371 0.80 PARP1 (0.41) IDO1TSHRPARP1
SCHEMBL7711115 0.80 AAK1 (0.40) HSD17B1HSD17B2CTSSCTSKAAK1
SCHEMBL7713423 0.79 PARP1 (0.41) SMYD3IDO1TSHRPARP1PDE3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1015437-B1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AG (DE) 2003-12-03 EP disclosed
US-6365736-B1 TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. SCHERING AKTIENGESELLSCHAFT (DE) 2002-04-02 US disclosed
EP-1015437-A1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AKTIENGESELLSCHAFT (DE) 2000-07-05 EP disclosed
WO-1999012915-A1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AKTIENGESELLSCHAFT (DE) 1999-03-18 WO disclosed