Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 2/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SNCA | P37840 | 1/20 | 0.39 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28999961 | 0.87 | MAPT (0.53) | ATMTDP1KCNMA1MAPTLMNA | |
| SCHEMBL404750 | 0.82 | TDP1 (0.53) | ATMTDP1KCNMA1MAPTLMNA | |
| SCHEMBL404749 | 0.81 | ATM (0.52) | ATMTDP1KCNMA1MAPTLMNA | |
| SCHEMBL621197 | 0.81 | TDP1 (0.52) | ATMTDP1KCNMA1MAPTLMNA | |
| Hydrochloric Acid SCHEMBL26110373 | 0.81 | TDP1 (0.52) | ATMTDP1KCNMA1MAPTLMNA | |
| SCHEMBL4817687 | 0.81 | ATM (0.52) | ATMTDP1KCNMA1MAPTPDE7A | |
| SCHEMBL539834 | 0.77 | TDP1 (0.47) | ATMTDP1KCNMA1MAPTALDH1A1 | |
| SCHEMBL22064874 | 0.77 | TDP1 (0.47) | ATMTDP1KCNMA1MAPTLMNA | |
| SCHEMBL16111494 | 0.77 | TDP1 (0.47) | ATMTDP1KCNMA1MAPTLMNA | |
| SCHEMBL1668405 | 0.77 | L3MBTL1 (0.54) | ATMTDP1KCNMA1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921119-B1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-07-02 | — | — | EP | disclosed |
| US-6114360-A | Pyrrole compounds | ADIR ET COMPAGNIE (FR) | 2000-09-05 | — | — | US | disclosed |
| US-6063804-A | Pyrrole compounds | ADIR ET COMPAGNIE (FR) | 2000-05-16 | — | — | US | disclosed |
| EP-0921119-A1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-06-09 | — | — | EP | disclosed |