Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 13/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ASIC3 | Q9UHC3 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3141716 | 0.76 | IDO1 (0.44) | IDO1CYP3A4ADRA2AADRA2BCYP2E1 | |
| Hydrochloric Acid SCHEMBL11257477 | 0.74 | IDO1 (0.43) | IDO1CYP3A4ADRA2AADRA2BCYP2E1 | |
| SCHEMBL3634371 | 0.72 | IDO1 (0.44) | IDO1CYP3A4ADRA2AADRA2BCYP2E1 | |
| SCHEMBL191327 | 0.70 | — | — | |
| SCHEMBL26259992 | 0.68 | ADRA2A (0.66) | IDO1CYP3A4ADRA2AADRA2BCYP2E1 | |
| Ethylene SCHEMBL17502485 | 0.67 | CYP3A4 (0.62) | IDO1CYP3A4ADRA2AADRA2BCYP2E1 | |
| SCHEMBL7194641 | 0.64 | IDO1 (0.59) | IDO1CYP3A4CYP2E1CYP2D6CYP2A6 | |
| SCHEMBL26260004 | 0.64 | IDO1 (0.58) | IDO1CYP3A4ADRA2AADRA2BCYP2E1 | |
| SCHEMBL12075152 | 0.64 | IDO1 (0.54) | IDO1CYP3A4CYP2E1CYP2D6CYP2A6 | |
| SCHEMBL26259980 | 0.64 | IDO1 (0.64) | IDO1CYP3A4ADRA2AADRA2BCYP2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177195-B1 | 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER LAMBERT CO (US) | 2003-03-19 | — | — | EP | disclosed |
| EP-1177195-A1 | 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER-LAMBERT COMPANY (US) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000066584-A1 | 1-AMINO TRIAZOLO¢4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER-LAMBERT COMPANY (US) | 2000-11-09 | — | — | WO | disclosed |