Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 17/20 | 0.48 |
| ▸ | TACR2 | P21452 | 13/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7006354 | 0.94 | TACR3 (0.47) | TACR3TACR2OPRM1KCNH2TRPV4 | |
| SCHEMBL7090056 | 0.80 | TACR3 (0.48) | TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL7002820 | 0.78 | TACR2 (0.55) | TACR3TACR2OPRM1KCNH2TRPV4 | |
| SCHEMBL6996763 | 0.75 | TACR3 (0.54) | TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL27745642 | 0.75 | TACR3 (0.55) | TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL5908766 | 0.75 | TACR2 (0.80) | TACR3TACR2OPRM1TRPV4 | |
| SCHEMBL6902393 | 0.75 | TACR2 (0.80) | TACR3TACR2OPRM1TRPV4 | |
| SCHEMBL6999257 | 0.73 | TACR3 (0.53) | TACR3TACR2OPRM1KCNH2TRPV4 | |
| SCHEMBL4667051 | 0.72 | TACR3 (0.55) | TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL5908758 | 0.71 | TACR2 (0.79) | TACR3TACR2OPRM1TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351953-A1 | QUINOLINE DERIVATIVES AS NK-3 ANTAGONISTS | GlaxoSmithKline S.p.A. (IT) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002044165-A1 | QUINOLINE DERIVATIVES AS NK-3 ANTAGONISTS | GLAXOSMITHKLINE SPA (IT) | 2002-06-06 | — | — | WO | disclosed |