Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 19/20 | 0.54 |
| ▸ | TACR2 | P21452 | 12/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5908755 | 0.79 | TACR2 (0.70) | TACR3TACR2OPRM1 | |
| SCHEMBL27745642 | 0.78 | TACR3 (0.55) | TACR3TACR2KCNH2OPRM1 | |
| SCHEMBL6996768 | 0.78 | LMNA (0.63) | TACR3TACR2KCNH2OPRM1 | |
| SCHEMBL6854969 | 0.77 | TACR2 (0.63) | TACR3TACR2KCNH2OPRM1 | |
| SCHEMBL6853990 | 0.76 | TACR3 (0.61) | TACR3TACR2KCNH2OPRM1 | |
| SCHEMBL6999030 | 0.75 | TACR3 (0.48) | TACR3TACR2KCNH2OPRM1 | |
| SCHEMBL4667074 | 0.74 | TACR3 (0.53) | TACR3TACR2KCNH2OPRM1 | |
| SCHEMBL7002820 | 0.74 | TACR2 (0.55) | TACR3TACR2KCNH2OPRM1 | |
| SCHEMBL6848956 | 0.74 | TACR2 (0.61) | TACR3TACR2KCNH2OPRM1 | |
| SCHEMBL4665274 | 0.73 | TACR3 (0.45) | TACR3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351953-A1 | QUINOLINE DERIVATIVES AS NK-3 ANTAGONISTS | GlaxoSmithKline S.p.A. (IT) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002044165-A1 | QUINOLINE DERIVATIVES AS NK-3 ANTAGONISTS | GLAXOSMITHKLINE SPA (IT) | 2002-06-06 | — | — | WO | disclosed |