Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 5/20 | 0.43 |
| ▸ | TDO2 | P48775 | 2/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999540 | 1.00 | EGFR (0.51) | EGFRERBB2HPGDHTTSOS1 | |
| SCHEMBL6999532 | 0.84 | EGFR (0.48) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8319396 | 0.83 | EGFR (0.57) | EGFRERBB2HPGDHTTSOS1 | |
| SCHEMBL8319391 | 0.83 | EGFR (0.57) | EGFRERBB2HPGDHTTSOS1 | |
| SCHEMBL8316336 | 0.81 | EGFR (0.57) | EGFRERBB2HPGDHTTSOS1 | |
| SCHEMBL8316342 | 0.81 | EGFR (0.57) | EGFRERBB2HPGDHTTSOS1 | |
| SCHEMBL6999264 | 0.81 | EGFR (0.65) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL4351961 | 0.80 | EGFR (0.60) | EGFRERBB2HPGDHTTSOS1 | |
| SCHEMBL6996566 | 0.80 | EGFR (0.60) | EGFRERBB2HPGDHTTSOS1 | |
| SCHEMBL8317350 | 0.79 | EGFR (0.56) | EGFRERBB2HPGDHTTSOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | disclosed |
| EP-0888351-A1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032880-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-09-12 | — | — | WO | disclosed |